Journal of Hematology & Thromboembolic Diseases
Open Access

Department of Pharmacology, Telangana, India

Publications

• Short Communication   
  Microfluidic Hemophilia Models using Blood
  Author(s): Nikitha Gandla*
  
  Microfluidic clotting tests allow sedate activity ponders for hemophilia therapeutics beneath stream. Be that as it may, constrained accessibility of understanding tests and Inter‐donor changeability constrain the application of such tests, particularly with numerous patients on prophylaxis. To create approaches to phenocopy hemophilia utilizing altered solid blood in microfluidic measures. Corn trypsin inhibitor (4 μg/mL)‐treated solid blood was dosed with either anti–factor VIII (FVIII; hemophilia A show) or a recombinant calculate IX (Settle) missense variation (FIX‐V181T; hemophilia B demonstrate). Treated blood was perfused at 100 s−1 divider shear rate over collagen/tissue calculate (TF) or collagen/factor XIa (FXIa). Anti‐FVIII in part blocked fibrin generation on collagen/TF, but totally blocked fibrin gener.. View More»
  DOI: 10.35248/2329-8790.20.8.317

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