Journal of Clinical Toxicology
Open Access

Nihon Bio Data Corporation, 1-2-3 Sakado, Takatsu-ku, Kawasaki, Kanagawa, Japan

Publications

• Research Article   
  Synergic Interaction between Permethrin and Bt Toxin Discovered Using RNA-seq
  Author(s): Takuma Sakamoto, Toshinori Kozaki and Norichika Ogata*
  
  Background: Acting against the development of resistance to antibiotics and insecticides, involving Negatively correlated Cross-Resistance (NCR) is an alternative to use-and-discard approach. It is termed NCR that toxic chemicals interact with each other and resistance of target organisms to one chemical is sometimes associated with increased susceptibility to a second chemical when; an allele confers resistance to one toxic chemical and hyper- susceptibility to another, NCR occurs. However, only 11 toxin pairs have been revealed to cause NCR in insects. Finding novel NCRs is needed for integrated pest management. Result: We analyzed permethrin, an insecticide, induced transcriptomes of cultured fat bodies of the silkworm Bombyx mori, a lepidopteran model insect. Differentially expressed gene analyses suggested Baci.. View More»
  DOI: 10.35248/2161-0495.22.12.519

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