Journal of Clinical Trials
Open Access

Department of Internal Medicine, Medical University of Graz, Graz, Austria

Publications

• Case Report   
  Malignant Baclofen Induced Coma Reversible by Dialysis in a 67-Year Old Patient with Acute Kidney Injury
  Author(s): Oliver Malle*, Tadeja Urbanic Purkart and Karin Amrein
  
  Introduction: Baclofen is a commonly used drug for the treatment of muscular spasticity and other conditions such as pain, alcohol withdrawal and myoclonus and is contraindicated in chronic kidney disease. Eliminated predominantly by the kidneys, acute renal insufficiency can lead to acute baclofen overdose with central nervous system affection caused by accumulation. Currently, there is no consensus about the treatment of baclofen intoxication. However, several reports showed that haemodialysis can effectively clear baclofen. We report a 67-yearold patient with baclofen intoxication caused by acute kidney failure presenting in a deeply comatose state that could be completely reversed within hours after one single haemodialysis. Case report: A 67-year-old woman was admitted with altered mental status and vomiting. Initially s.. View More»
  DOI: 10.35248/2167-0870.22.S17.003

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