Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
Dr. Omid Reza Zekavat is an Associate Professor in Department of Pediatrics at Shiraz University of Medical Sciences, Iran. He have published more than 30 articles in high standard Journals. His area of interest includes Hematology, Oncology, Biomedical Sciences, Molecular Biology, Biotechnology.
Research Article
Increased Frequency of KIR2DS4 del/del among AA Genotype Carriers with B-Cell Acute Lymphoblastic Leukemia in Southwestern Iranian Population
Author(s): Sepide Namdari, Mohammad Reza Bordbar, Omid Reza Zekavat and Shirin Farjadian*
Acute Lymphoblastic Leukemia (ALL) is known to be the most common malignancy among children. The early onset of ALL suggests a key role of genetic factors in its development. Killer Cell Immunoglobulin-like Receptor (KIR) gene complex that encodes a group of key receptors expressed at the surface of natural killer cells has been of great interest as a possible genetic factor affecting the susceptibility to ALL. In this case-control study, we aimed to verify whether the inheritance of specific KIR genes or genotypes were associated with susceptibility to childhood B-ALL in southwestern Iranian population. To this end, KIR genotyping was carried out for 120 patients with childhood B-ALL and 170 unrelated healthy controls using PCR-SSP method. The frequencies of 11 KIR genes and KIR2DS4 variants were investigated among patients and healthy controls. We found no association between KIR ge.. View More»
DOI:
10.35248/igoa.21.6.134