Clinical Pediatrics: Open Access
Open Access

Department of Neurosurgery, University of Health Sciences, Istanbul, Turkey

Publications

• Research Article   
  Management of Hyperleukocytosis and Results of Leukapheresis in Childhood Acute Leukemia: A Single Center Experience and Review of the Literature
  Author(s): Ozlem Terzi*
  
  Background: Hyperleukocytosis in pediatric acute leukemia is associated with increased morbidity/mortality and there is no consensus on the use of Leukapheresis (LP) for its management. The aim was to review patients' clinical characteristics and outcomes with newly diagnosed leukemia with Hyperleukocytosis (HL). Methods: A retrospective case control study reviewed data from a single institution over a 5-year period. Hyperleukocytosis was present in 41 patients with acute leukemia and were included in the study. Treatment strategies included hyperhydration, administration of allopurinol or rasbirucase, early induction of induction Chemotherapy (CT) and LP. Results: Twenty seven (65.9%) of the 41 patients were male and the median age was 7 (range 1-17) years. LP was used in 9 of 41 (13%) patients with hyperle.. View More»
  DOI: 10.35248/2572-0775.24.09.276

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