Journal of Clinical & Experimental Dermatology Research
Open Access

Department of Plastic Surgery, Akdeniz University School of Medicine, Antalya, Turkey

Publications

• Research Article   
  Research of Notch-1 Expression with Immunohistochemical Method in Malignant Melanoma
  Author(s): Zeynep Bayramoglu*, Betul Unal, Ozlenen Ozkan and Cumhur Ibrahim Bassorgun
  
  Background: Currently, several new treatment strategies targeting specific signaling pathways and immunotherapy are being explored for malignant melanoma. We investigated the relationship between notch-1 gene expression by immunohistochemistry in patients with malignant melanoma. Objective: We investigated the relationship between malignant melanoma and notch-1 in this study. Methods: In our study, 10 patients with intradermal nevus and 27 patients with malignant melanoma were studied by immunohistochemistry with notch-1. Results: We found notch-1 expression in 11 of our 27 patients. There was a significant correlation between sentinel lymph node metastasis and notch-1 expression (p<0,05). Our study has shown that the notch signaling pathway is associated with sentinel lymph node metas.. View More»
  DOI: 10.35841/2329-9509.23.15.672

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