Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Institute for Personalized Medicine, Tbilisi State Medical University, Tbilisi, Georgia
Research Article
Prognostic and Predictive Biomarkers in Triple Negative Breast Cancer (TNBC): A Comparative Study of Glycolysis, Inflammatory Markers, Melatonin, Neurotransmitters and Metalloproteinases
Author(s): Alexandre Tavartkiladze*, Gaiane Simonia, Pati Revazishvili, Maia Maisuradze, Dinara Kasradze, Givi Tavartkiladze, Rusudan Khutsishvili and Irine Andronikashvili
Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptors, progesterone receptors and Human Epidermal growth factor Receptor 2 (HER2) amplification. This study aimed to identify prognostic and predictive biomarkers associated with disease progression in TNBC. We compared glycolysis indicators, inflammatory markers, neurotransmitters, Matrix Metalloproteinases (MMPs) and adaptive biomarkers across three groups such as patients with advanced TNBC, non-advanced TNBC (T1N0M0G1) and healthy controls.
Our results showed significant metabolic reprogramming in TNBC, with elevated lactate and pyruvate levels indicating a reliance on glycolysis. Inflammatory markers such as Interleukin-6 (IL-6) and Tumor Necrosis Factor (TNF) alpha were markedly increased in advanced TNBC, reflecting a chronic inflammatory state t.. View More»