Andrology-Open Access
Open Access

Molecular Genetics Scientific Laboratory, Riga Stradins University, Dzirciema 16, LV-1007 Riga, Latvia

Publications

• Mini Review   
  The Ouroboros of Human Evolution: Global Decline of Male Fertility and Increase in Cancer
  Author(s): Jekaterina Erenpreisa*, Ninel M Vainshelbaum, Kristine Salmina, Pawel Zayakin and Juris Erenpreiss
  
  Two global tendencies: The decline in male fertility and increase in cancer are very alarming. Here we present the extended Mini-Review of the recently published article and some literature references analyzing the reciprocal link (ouroboros) of both pathologies. We showed that it was rooted in multicellular evolution and became enhanced by current environmental pollution and endocrine disruption. The findings are based on the phylostratigraphic analysis of the networked functional modules of ~1500 gametogenic genes which have evolved from Unicellulars to Homo sapiens. The evolutionary key to the link for male reproduction and cancer was revealed in the multicellulars of the Cambrian explosion (~500 Mya) when innate immunity/inflammation (including the proto-placental genes) and hormonal sex determination emerged, shared and hubbed by stress-response genes FOS/JUN and cytokine IL1&bet.. View More»
  DOI: 10.35248/2167-0250.23.12.293

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