Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Proctology, Zaozhuang Hospital of Traditional Chinese Medicine, No 24 Gongsheng road, Shizhong District, Zaozhuang City, Shandong Province, 277100, China
Research Article
Comprehensive Analysis of Immune Related Genes in the Tumor Microenvironment of Colorectal Cancer
Author(s): Deyu Chen, Peng Han and Feng Yang*
Objective: This study was therefore designed to conduct a robust analysis of Colorectal cancer (CRC) immune
microenvironment to identify specific genes and pathways that can be targeted in an effort to achieve more effective
immunotherapy outcomes.
Methods: Using five Independent data sets, we analyzed expression profiles associated with 29 different immune
signatures, and we used these profiles to guide the hierarchical clustering of CRC samples based on their immune
micro environmental composition
Results: We were able to cluster our CRC samples based on whether they had exhibited high, medium, or low levels
of infiltration by immune cell types associated with tumor clearance (Immunity-H, Immunity-M, and Immunity-L,
respectively). Samples in the Immunity-H subset exhibited a “hot” immune.. View More»