Journal of Tumor Research
Open Access
ISSN: 2684-1258
ISSN: 2684-1258
Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Research Article
Revealing Toxic Proteins of the Craniopharyngioma Cyst Fluid: A Proteomics Approach
Author(s): KVL Narasingha Rao, Omkar Shirke, Vivek Ghose, Rahul R Patil, Yogananda S Markandeya, Periyasamy Govindaraj, Bhupesh Mehta* and Manish Beniwal*
Craniopharyngioma although benign, is one of the most difficult tumors to resect and manage. The fluid inside the tumors is known to accumulate even after aspiration leading to tumor recurrence. Spontaneous rupture of the tumor leads to leakage of the cyst fluid to the surrounding tissue and is known to cause aseptic meningitis. This study aimed to identify toxic proteins in the cyst fluid which could be responsible for altering the normal physiology of the surrounding brain tissue. We first characterized the proteomic content of the cyst fluid collected from 12 patients by tandem mass spectrometry which revealed 91 common proteins. These proteins were then subjected to bioinformatics analysis to identify the biological processes, cell components and molecular functions of the proteins and were further compared with the proteins involved in neurodegenerative diseases to narrow our sea.. View More»
DOI:
10.35248/2684-1258.24.10.234