ISSN: 2155-9600
+32 25889658
R&D Indena SpA, Viale Ortles 12-20139 Milan, Italy
Pietro Allegrini, was working as an independent researcher based in Italy, International experience includes various programs, contributions and participation in different countries for diverse fields of study.
Research Article
Targeting Cannabinoid Receptors and Fatty Acid Amide Hydrolase: An Innovative Food-Grade Delivery System of Zingiber officinale and Acmella oleracea Extracts as Natural Adjuvant in Pain Management
Author(s): Giovanna Petrangolini, Fabio Donzelli, Davide Berlanda, Pietro Allegrini, Andrea Rossignoli, Michela Stucchi and Antonella Riva*
Background: Anti-inflammatory and analgesic properties are displayed by several natural products, in particular
Acmella oleracea and Zingiber officinale. Literature data suggests that both botanical extracts can be useful as
inflammation/pain modulators, so technological efforts have been made to associate them together in a unique
delivery new food-grade formulation, Mitidol, with the purpose of improving their beneficial effects.
Objective: The aim of the present work was to assess if Mitidol and its active ingredients are able to modulate the
endocannabinoid 2 receptor system, one of the major systems responsible for positive effects of Cannabis treatment.
Cannabinoid 2 receptor represents an attractive pharmacological target in obtaining an anti-inflammatory/analgesic
effect with low central nervous sy.. View More»
DOI:
10.35248/2155-9600.20.10.1000766