Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Plant Immunity Laboratory, National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India
Commentary Article
Role of ArF-BAR in Fungal Pathogenesis
Author(s): Praveen Kumar Verma* and Ankita Shree
The establishment of invaginations and protrusions in the plasma membrane and the shaping of intracellular organelles require equilibrium between generation and stabilization of membrane curvature. The intrinsic shape of BAR-(Bin–Amphiphysin–Rvs) superfamily proteins helps them to bind and generate curvature in the plasma membrane. Thus, evolutionarily conserved BAR domain-containing proteins act as the central regulator of membrane dynamics. Loss-of-function mutation of the F-BAR domain-containing gene in Ascochyta rabiei (ArF-BAR) results in compromised virulence. ArF-BAR participates in various cellular functions including endocytosis, actin polymerization, oxidative stress tolerance, penetration of the fungal hyphae in the host tissue, formation of septa, and secretion of a fungal effector. ArF-BAR functions downstream to stress-responsive transcripti.. View More»
DOI:
10.35841/2165-8056.22.12.199