Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, China
Short Communication
Spermidine Related Autophagy Flux Deficiency is a Novel Pathogenesis of
Aplastic Anemia
Author(s): Jian Li, Qiyuan Li*, Guo Fu, Qing Li, Zunnan Huang, Yongjian Su, Shunqing Wang, Ruiqing Zhou*, Kefeng Wu*, Qinwei Chen, Jinqi Huang*, Yuchan You, Changmei Lin, Jie Long, Liang Liang, Sijie Wang, Chen Yang, Juan Xia and Yuming Zhang
Aplastic Anemia (AA) is a hematopoietic failure symptom of the bone marrow that can be caused by a variety of
factors such as T-cell mediated immune attack, genetic-related somatic mutations, cytogenetic abnormalities, and
defective telomerase functions. Recently, Single-cell RNA-sequencing (scRNA-seq) analysis of bone marrow-derived
Hematopoietic Stem and Progenitor Cells (HSPCs) from AA patients also revealed the involvement of selective
lineage disruption, altered alternative splicing, and polyadenylation in AA pathogenesis . However, these new
mechanisms did not provide any new therapeutic approaches for AA, as novel therapies are urgently needed for
patients who received no durable benefit from immunosuppressive therapy combined with the Thrombopoietin
Receptor (TpoR) activator and patients who underwent allogeneic hematopoietic stem cell transplantation. The.. View More»
DOI:
10.35248/2155-9899.22.13.669