Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
Research
Associations between Phascolarctobacterium/Phascolarctobacterium faecium and Disorders of Glucose and Lipid
Metabolism in Type 2 Diabetes Mellitus-A Case Control Study
Author(s): Lisha Li, Qiongying Hu and Daqian Xiong*
Background: Host-microbiome dysbiosis have been linked to Type 2 Diabetes Mellitus (T2DM). The purpose of this paper is to investigate whether Phascolarctobacterium and Phascolarctobacterium faecium (P. faecium) serve as ideal biomarkers for T2DM. On this basis, to evaluate the key role of multi-omics analysis in the early diagnosis of T2DM.
Method: Detected stool samples from healthy people, T2DM patients and T2DM patients after metformin treatment in our cohort study by 16S ribosomal Ribo-Nucleic Acid (rRNA) gene amplicon sequencing. In addition, various baseline clinical and metabolic index were collected to evaluate the diagnostic models of Receiver Operator Characteristic (ROC) curves which combined use of intestinal bacteria, fatty acids and micro Ribo-Nucleic Acid (miRNA) as predictive tools for early detection of T2.. View More»
DOI:
10.35248/0974-276X.23.16.655