Medicinal & Aromatic Plants
Open Access

Department of Studies in Molecular Biology, University of Mysore, Manasagangothri, Mysore, India

Publications

• Research Article   
  Appraisal of Antiophidian Properties of Cardiospermum halicacabum L. Leaf and Callus Extracts against Naja Naja Venom
  Author(s): Dr. Girish HV*, Nataraju A, Rajaiah R, Vishwanath BS, Sudarshana MS and Reshi NA
  
  Considering the limitations of antivenom therapy towards toxicity following envenomation, investigators are probing for effective phytochemicals with promising antivenom effects. In the current study, Cardiospermum halicacabum leaf and callus methanol extracts were investigated for their ability to neutralize Indian cobra (Najanaja) venom. Soxhlet extraction using methanol was performed since leaf and callus extracts demonstrated significant neutralization of N. najavemon in preliminary studies. In vitro neutralizing potential of both extracts were evaluated against phospholipase A2, preoteases and hyaluronidases. In addition, alleviation of N. naja-induced characteristic edema inducing activity, myotoxicity and coagulation, hemolytic activity were performed in mouse models and human blood samples. Leaf and callus methanol extract contained.. View More»
  DOI: 10.35248/2167-0412.21.10.399

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