ISSN: 2329-6631
+44 1478 350008
Department of Pharmaceutical science, Roorkee College of pharmacy, Uttarakhand, India
Research Article
Formulation and Evaluation of Mouth Dissolving Tablets Prepared by Micronized Terbutaline Sulfate and Using Co-processed Superdisintegrants by
Direct Compression Method
Author(s): Dinesh Sharma*, Rajesh Aggarwal and Rajeev Tomar
The present work contains details of formulating and evaluation of mouth dissolving tablets of micronized
terbutaline sulphate by using co-processed superdisintegrants and taste masking agent (flavors and ion exchange
resin) with an aim to get a dosage form having fast disintegration.
Terbutaline sulphate first pass through size reduction technique which leads to increase in surface area and increased
in oral absorption of the drug. As a part of pre-formulation study, the physicochemical compatibility study of the
drug with different excipients was done and drug-excipient interaction was assessed from thermal analysis by using
differential scanning calorimetry indicated absence of interactions between the selected excipients for the study.
Moisture absorption study of the drug indicated that the drug is non-hygroscopic. Thermal (stress) Stability of the
dr.. View More»
DOI:
: 10.35248/2329-6631.22.11.179