Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia
Review Article
Diagnostic Challenges and Immunological Barriers in Kidney Transplantation
Author(s): Rayan Bawayan*, Khalid Elhassan and Ashraf Dada
The presence of donor specific antibodies and HLA-incompatibility between waiting list patients and potential donors make transplantation programs worldwide complicated and stand as a major barrier for a quick access for organ transplantation. Especially in kidney transplantation, the effector HLA antibodies are the most important reason for graft failures and antibody mediated rejection. At the same time, the demand for kidney transplantation is increasing remarkably worldwide, due to the continuously Raising number of patients with end stage renal disease. For these patients, hemodialysis was regularly considered as an intermediate step only and the ideal goal is to find a suitable kidney as early as possible. However, in case of HLA-incompatibility, the waiting time for an organ is too long and often accompanied with dialysis associated multiple diseases, including physi.. View More»
DOI:
10.35248/2155-9899.23.14.687