Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Dept. of Obst & Gynecology, Shadan Institute of Medical Sciences, Medical and Research Director, Medical Health and Research Institute (MHRI), India
Research Article
Impact of Mitochondrial Oxidative Phosphorylation Dysfunction in the Patient with Endometriosis
Author(s): Roya Rozati*, Aleem Ahmed Khan, Wajeeda Tabasum, Salwa Sahar Azimi, Vikram Aiman Ayapati, Ayapati Gautam Mehdi, Nasaruddin Khaja, Krishnan Sivaraman and Sripriya Vennamaneni
Background: Endometriosis is a chronic inflammatory condition where the precise cause of endometriosis is still not unclear. Mitochondrial dysfunction has been reported in severe forms of endometriosis. However, the role of mitochondrial dynamics, mitophagy, and mitochondrial-related complexes in endometriosis and its relation with Epithelial-Mesenchymal Transition (EMT) is not clear.
Objective: Therefore, this study aims to elucidate the role of mitochondrial dysfunction and its relation with EMT in the pathogenesis of endometriosis.
Material and methods: At present, cell viability, immunophenotypic enrichment using flow cytometry, and gene expression by real-time quantitative PCR were carried out.
Results: A significant decrease in the expression of OXPHOS genes, DRP1, Pink-1, Parkin, and E-cadh.. View More»
DOI:
10.35248/2161-0932.24.14.4.621