Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Department of Genetics, Mexican Institute of Social Security Mexico City, Mexico
Research Article
Circulating Y-RNAs: A Predicted Function Mainly in Controlling the Innate Immune System, Cell Signaling and DNA Replication in Pediatric Patients with Pilocytic and Diffuse Astrocytoma
Author(s): Juan Manuel Rodríguez-Corona, Ruth Ruiz Esparza-Garrido, Jorge Víctor Horta Vega and Miguel Angel Velazquez Flores*
Background: Y-RNAs are small noncoding RNAs firstly identified in patients suffering the Sjogren’s syndrome and lupus erythematosus, having different predicted cellular functions. Y-RNAs are very abundant ncRNAs present in serum and only a few is known respect their molecular roles.
Objective: The aim of the study was to determine the circulating Y-RNAs expression from blood serum of pediatric patients with pilocytic or diffuse astrocytoma.
Materials and methods: Y-RNAs expression was determined by means of the Human Transcriptome Array (HTA) 2.0 arrays. In addition, a bioinformatic approximation of the possible biological functions of Y-RNAs was determined with the Random Forest (RF) and Vector Support Machine (VSM) algorithms.
Results: Data showed a differential expression of RN.. View More»
DOI:
10.35248/2572-0775.23.8.239