Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Bioinformatics, University of Madras, India
Research Article
Rejuvenating the Gut of Antibiotic Incited Zebrafish (Danio Rerio) by Probiotic Soil Isolates Persuaded by Subtilisin as Endogenous Protease Inhibitors
Author(s): Arockiya Anita Margret*, S Aishwarya, A Shree Parkavi, V Swetha, T Suvedha and G Sandhya
Antibiotics are extensively used as therapeutics against various human and veterinary ailments. It is also used to promote livestock growth, which can be hazardous by its dispersion in water bodies and lead to aquatic toxicity. Antibiotic-associated diarrhea (AAD) is a common complication caused due to the adverse effects of antibiotic administration. It is necessary to have a better understanding on consumption of probiotics, possessing natural endogenous protease inhibitors and its mechanism to target protease from gut pathogens. Subtilisin are group of proteases originated from Bacillus spp and a molecular docking study revealed its inhibitory potential (-1.90 KJ/Mol) against a target protein Clostridium difficile toxin. The bacterial isolates from the vegetative soil were identified as Aneurinibacillus migulanus and assayed for probiotic efficiency. The production of subtilisin fr.. View More»