Journal of Clinical & Experimental Dermatology Research
Open Access

Elite Derma Care Clinic, Dr. Layla Al-Onaizi Polyclinic, Khobar 31952, Saudi Arabia

Publications

• Review Article   
  Anti-Aging Effects of Nicotinamide Riboside (NR) Supplementation
  Author(s): Saad AlSogair*
  
  Sirtuins show promise in prolonging lifespan, as shown by previous animal and human studies. They play a role in cellular responses against oxidative stress and in cellular metabolism while also maintaining the length of telomeres. To make sirtuins work, cells need NAD+. The bioavailability of NAD+ inside the cells decreases in normal aging and may add to physiological aging by decreasing the action of sirtuins. The NAD+ metabolites nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), which are forms of vitamin B3, can increase NAD+ levels and improves different physiological capacities in animal studies. Among these two metabolites, nicotinamide riboside (NR) is more available in food and has better cell permeability, since it does not require any transformation to different intermediates. NR is also proven to be safe by studies, while NMN is yet to demonstrate safety in.. View More»
  DOI: 10.35248/2155-9554.20.11.535

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