Journal of Leukemia
Open Access

Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran

Biography

Dr Saeideh Saeb is the Associate Professor in the Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran. Currently, Dr. Saeideh Saeb is the author/reviewer in several international journals. He published 7 carticles in journals and the articles are informative and got good citations.

 

Publications

• Research Article   
  Effects of Vitamin A and D on DNA Methyltransferases 3A and 3B Expression and Neural Stem Cell Differentiation
  Author(s): Pooneh Mokarram*, Parisa Alizadeh, Saeideh Saeb, Nasim Rahmani-Kukia, Marzieh Babazadeh and Morvarid Siri
  
  Background: In Multiple Sclerosis (MS) as the demyelination happens, Oligodendrocyte Precursor Cells (OPCs) migrate to the site of injury and start differentiating into mature oligodendrocytes to regenerate the myelin sheaths. This OPC differentiation process can be affected by the epigenetic mechanisms which are mediated by a family of DNA methyltransferases (DNMTs) such as DNMT3A and DNMT3B. However, Dietary factors can alter the DNMTs expressions and even their activities. Therefore, in this study the effect of dietary factors such as vitamin A and D on the expression of DNMT3A and DNMT3B genes was assessed during these cells. Methods: Rat embryonic stem cells were derived from ganglionic eminence. Then, the stem cells were cultured, differentiated and divided into five groups: control negative, control positive and three.. View More»
  DOI: 10.35248/2329-6917.21.9.270

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