Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Medical Physiology, Assiut University, Assiut, Egypt
Research Article
Effect of Urea on Lens Protein of Multi-lamellar Bodies in Senile Nuclear Cataract
Author(s): Hassan L. Fahmy*, Sally A. Sayed, Mohamed G.A. Saleh, Mohamed Anwar and Ghada Hosny
Addressing the biochemical and physical changes leading to development of cataract and reversal of this process is research target for ophthalmologists. Currently the only way to treat cataract is by surgical intervention which entails a big economic and logistic burden especially in underdeveloped nations and is not risk free. In this ex vivo experiment, we injected urea solution in a concentration of 96 mmol/L in hard cataractous nuclei removed by cataract surgery. Results showed that urea restored transparency of these opaque nuclei. Electron microscopic examination of those lenses before and after injection showed disorganization of lamellar bodies (hallmark sign of cataract) with restoration of the regular pattern of extracellular spaces within the lens and hence better light transmission. This observation may carry the potential for us to be able to develop a way to pre.. View More»
DOI:
10.35248/2155-9570.23.14.946