Journal of Hepatology and Gastrointestinal disorders
Open Access
ISSN: 2475-3181
+44-77-2385-9429
ISSN: 2475-3181
+44-77-2385-9429
Anatomic Pathology Department, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia
Case Report
Acquired Factor X Deficiency in Amyloid Light-Chain Amyloidosis Associated with Myeloma: A Case Report
Author(s): Cyrine Makni Mehrez*, Lamine Hamzaoui, Moufida Mahmoudi, Amal Khsiba, Hend Ayadi, Emna Chalbi, Saloua Nechi, MounaMedhioub and Mouhamed Mousadek Azouz
Introduction: Systemic AL amyloidosis is a serious disease. Its prognosis depends on the extent of the amyloid
deposits and the extent of cardiac involvement. Without effective treatment, the median survival is approximately 12
months. About 10% of patients with multiple myeloma have associated AL amyloidosis. The survival of patients with
AL amyloidosis and MM is significantly less than the survival of patients with AL amyloidosis alone. Otherwise,
hepatic involvement is frequent, and it is reported in 70% of patients with amyloidosis. Factor X deficiency is a
possible but rare complication of primary AL amyloidosis (6% of cases). It is thought to be the consequence of
binding between factor X and amyloid in all organs, especially the liver and spleen.
Case: We report a case of hepatic AL amyloidosis associated with acquired.. View More»
DOI:
10.35248/2475-3181.22.8.206