Internal Medicine: Open Access
Open Access

Faculty of Medicine, Tanta University, Egypt

Biography

Sama Metwally works in the Department of Medicine, at Tanta University, Egypt, and a well-known researher and one of his famous works are Werner Syndrome: A Case Report of Two Brothers of Pangeria

Publications

• Case Report   
  Werner Syndrome: A Case Report of Two Brothers of Pangeria
  Author(s): Sama Metwally*, Loai El Ahwal, Khalid Zaghlol, Najwa Alwan and Raghda Gabar
  
  Werner syndrome is considered inherited premature ageing and genomic instability syndrome. It is an autosomal recessive disorder in which aging process is accelerated starting after puberty. It is also termed as Progeria adultorum. The hallmark features are short stature, senile facies, scleroderma like skin (dry atrophic skin, mottled darkness, telangiectasia, sclerodactyly, and gangrene), cataract, hypogonadism, contractures of skin over joint, premature atherosclerosis, loss of subcutaneous fat and ulcers over feet and leg. Treatment of painful ulcers is difficult with increased risk of malignancy (fibro sarcoma in 10% of patients). Death is usually occurring in the fourth to sixth decade due to myocardial infarction or malignancy. We reported 2 brothers of Pangeria of positive consanguinity parents the older is 40 years old, short stature, senile facies with bi.. View More»
  DOI: 10.35248/2165-8048.19.9.308

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