Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
MET’s Institute of Pharmacy, Bhujbal Knowledge City, Maharashtra, India
Research Article
Drug Repurposing Approach Targeting Main Protease Using HTVS and Pharmacophoric Mapping: Exceptional Reassuring Itinerary for Most Insolvent Anti-SARS-CoV-2 Drug
Author(s): Virupaksha A. Bastikar*, Pramodkumar Gupta, Jaiprakash N. Sangshetti, Alpana V. Bastikar and Santosh S. Chhajed
Coronavirus pandemic COVID 19 has caused a wide range of harm worldwide with its inception in December 2019
in Wuhan, China. Till date there is no promising drug identified for the treatment of disease. In the view of this,
scientists have elucidated X-ray structures of the proteins in SARS-CoV-2 virus. These can act as probable drug targets
for the designing of drugs which is urgent need. One of the main proteins of the virus is its main protease Mpro
which is responsible for producing polyproteins of the virus. In this study we have used main protease as the target for
drug design and repurposing for COVID-19. Two approaches were applied in order to develop a fast and effective
treatment against the virus. Drug repurposing through in-silico docking analysis of existing FDA approved drugs was
one method and high throughput screening of molecules from the.. View More»
DOI:
10.35248/0974-276X.21.14.527