Andrology-Open Access
Open Access
ISSN: 2167-0250
+44 1300 500008
ISSN: 2167-0250
+44 1300 500008
King Abdullah International Medical Research Center, Jeddah 22384, Saudi Arabia
Review Article
Androgen Receptor and the Fatty Acid-Binding Protein 5 in Malignant Progression of Prostate Cancer and in Development of Resistance to Treatment
Author(s): Abdulghani A Naeem, Saud A Abdulsamad, Jiacheng Zhang, Wenzhi Guo, Gang He and Youqiang Ke*
Background: Prostate cancer is one the most common cancers of men worldwide and a leading curse of death from male malignant diseases. Androgen Receptor (AR) and Fatty Acid-Binding Protein 5 (FABP5) play important roles in prostate cancer development, expansion, and malignant progression.
Objectives: In this short review, we intend to provide an overview on roles of AR and FABP5 play in development, progression of prostate cancer and the development of resistance to current treatment. We also intend to discuss the possible future effective treatment for Castration-Resistant Prostate Cancer (CRPC) which is currently an incurable disease.
Methods: The literature survey in this study was conducted by searching databases, including EBSCO Host information services, National Library of Medicine, Oxford Academic, Acta Pha.. View More»
DOI:
10.35248/2167-0250.25.14.340