Journal of Cell Science & Therapy
Open Access

Department of Radiation Oncology, Mass General Hospital, Boston, Massachusetts, United States

Publications

• Research Article   
  DNA Methylation Meta-Analysis Confirms the Division of the Genome into Two Functional Groups
  Author(s): Lev Salnikov*, Saveli Goldberg, Parvathy Sukumaran and Eugene Pinsky
  
  Based on a meta-analysis of human genome methylation data, we tested a theoretical model in which aging is explained by the redistribution of limited resources in cells between two main tasks of the organism: its selfsustenance based on the function of the Housekeeping Gene Group (HG) and functional differentiation, provided by the (IntG) integrative gene group. A meta-analysis of methylation of 100 genes, 50 in the HG group and 50 in IntG, showed significant differences (p<0.0001) between our groups in the level of absolute methylation values of genes bodies and its promoters. We showed a reliable decrease of absolute methylation values in IntG with rising age in contrast to HG, where this level remained constant. The one-sided decrease in methylation in the IntG group is indirectly confirmed by the dispersion data analysis, which also decreased in the genes of this group. The imb.. View More»
  DOI: 10.35248/2157-7013.22.S10.352

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