Journal of Clinical Toxicology
Open Access

Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan

Publications

• Case Report   
  A Case of Fluoroacetamide Poisoning Alleviated by Hemodialysis
  Author(s): Shigeo Higami*, Seiji Morita, Mariko Sugita, Rie Yamamoto, Takeshi Saito and Yoshihide Nakagawa
  
  Fluoroacetate poisoning, usually caused by exposure to sodium monofluoroacetate and fluoroacetamide, competitively inhibits aconitase in the tricarboxylic acid cycle. There are no effective antidotes, and treatment is symptomatic and supportive. The effectiveness of hemodialysis in alleviating fluoroacetate poisoning remains unclear, and no study has reported changes in the blood concentration of fluoroacetate after hemodialysis. A 71-year-old man with a history of chronic kidney disease and on maintenance hemodialysis had findings suggestive of acute fluoroacetate poisoning. He presented with tachycardia, tachypnea, renal dysfunction, hyperammonemia, and hyponatremia. He was intubated with a nasogastric tube and administered intravenous fluids, and direct hemoperfusion and hemodialysis were performed on successive days to reduce blood fluoroacetate concentrations. He recovered withou.. View More»
  DOI: 10.35248/2161-0495.21.11.477

  Abstract HTML PDF