Cell & Developmental Biology
Open Access

Istanbul University, Cerrahpasa, Chemical Engineering, Avcilar, Istanbul, Turkey

Publications

• Research Article   
  Synergistic Effect of Selenium and Genipin Triggers Viability of 3T3 Cells on PVA/Gelatin Scaffolds
  Author(s): Demet Erdag*, Serkan N. Koc, M. Faruk Oksuzomer and Leman Yalcintepe
  
  Naturel and non-cytotoxic porous scaffolds were obtained with poly(vinyl alcohol) (PVA) and gelatin (GE) using electrospinning and freze/drying methods. Electrospinning scaffolds were produced as PVA/GE/GA crosslinked with glutaraldehyde (GA) and freeze/drying scaffolds crosslinked with genipin (GP) were divided into two groups as PVA/GE/GP5 and PVA/GE/GP8, respectively, according to their genipin ratio. In addition, the main biological significants of genipin is anti-cancer; antibacterial; anti-inflammatuar; antidiabetic; antithrombotic. Selenium is known to increase the proliferation of cells and for its antibacterial properties. The scaffolds were investigated in terms of pore morphology, swell ratio, biodegradation, and biocompatibility. The biocompatibility of the material was tested in vitro by MTT assay on days 1, 2, and 3 to test the cell viability of mouse 3T3 fibroblast cell.. View More»
  DOI: 10.35248/2168-9296.21.s1.236

  Abstract HTML PDF