Lupus: Open Access
Open Access

Department of Immunology, Mashhad University of Medical Sciences,, Mashhad, Iran

Publications

• Mini Review   
  The Immunomodulatory Role of MSC as A Cell Therapy in Systemic Lupus Erythematosus
  Author(s): Sara Hosseini, Mahmoud Mahmoudi and Seyed-Alireza Esmaeili*
  
  Systemic lupus erythematosus (SLE) is a chronic multisystemic inflammatory autoimmune disorder. By far there aren’t any certain and clear etiopathogenesis for SLE, however, it has been well indicated that genetic susceptibility along with environmental factors drive the disturbance in immune tolerance so that SLE development will occur, through which both the innate and adaptive arms of the immune response exacerbate disease condition. To date, no absolute cure for SLE has been illustrated and current therapeutic strategies are primarily in terms of application of immunosuppressive drugs. Mesenchymal stem cells (MSC) are multipotent stem cells with low immunogenicity that can differentiate into different kinds of cells. Recently, Immunomodulatory functions of MSCs bring them as potential candidate for treating SLE. MSCs play a role in suppression of the ant.. View More»
  DOI: 10.35248/2684-1630.21.6.169

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