Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar,Dhaka, Bangladesh
Dr. Shahdat Hossain was born on 1 January 1967 in a village of Tangail District. He secured 9th position in Secondary School Certificate Examination (Agriculture Branch) of Dhaka Board in 1981. After completing his college education in Dahanbary Collge in 1983 from the same board he took admission in the University of Dhaka, Bangladesh, from where he earned his B.Sc. and M.Sc. degrees in Biochemistry. He then went to Shimane Medical University, Japan and earned his Ph.D. in 1999 from the Department of Physiology-I.
Research Article
Ganoderma lucidum Modulates Neuronal Distorted Cytoskeletal Proteomics and Protein-Protein Interaction in Alzheimer's Disease Model Animals
Author(s): Mohammad Azizur Rahman*, Shahdat Hossain, Noorlidah Abdullah and Norhaniza Aminudin
Background: Alzheimer’s disease (AD) is the leading neurodegenerative disorder affecting memory, learning and
behavior. Altered expression of proteins involved in neuronal structure and function is a recent observation of AD
pathogenesis. Modulation of altered protein expression seems promising in AD therapeutics. In the present
experiment, AD ameliorating effect of medicinal mushroom Ganoderma lucidum (GL) had been evaluated through its
effect on neuronal cytoskeletal structure and function related protein expression pattern in AD model rats.
Methods: Wistar male rats (120 ± 5 gm) were divided into three groups: control rat (CR), Alzheimer’s Disease Model
Rat (ADMR) and G. lucidum Hot Water Extract (GHWE) fed ADMR, each group containing 15 rats. AD model rats
were prepared by infusing Aβ1-4.. View More»
DOI:
10.35248/2165-8056.20.S1.002