Journal of Clinical and Cellular Immunology
Open Access

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA

Publications

• Mini Article   
  Dendritic Cells as Double-Agents for Breast Tumor Pre-Metastatic Bone Disease Establishment
  Author(s): Shane Groschel*
  
  Pre-metastatic niche formation at distant sites can be initiated by the primary tumor through “education” of nontumoral cells present in the primary cancerous niche. Among other participants, immune cells and their secreted factors can boost the successful seeding of the distant disease. Accordingly, we showed that RANKL production by breast tumor-primed T cells is required for development of bone metastasis. Pro-osteoclastogenic tumor-specific RANKL+ T cells were shown as messengers from the periphery to the bone marrow, where they alter bone turnover homeostasis in favour of osteoclasts and before tumor colonization. Pre-metastatic T cell-mediated osteolytic disease generates a rich environment that will allow further colonization of the bone cavity by the metastatic clones. Once initial seeding of the bone tissue is achieved, tumor cells can continue the osteolyt.. View More»
  

  Abstract PDF