Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Department of Urology, Yangjiang People's Hospital, Guangdong Medical University, Yangjiang, Guangdong, China
Research Article
Prognostic Marker of MMP9 Related to the Immune Cell Infiltration in the Tumor Microenvironment of Bladder Cancer
Author(s): Han-Sheng Lin, Wan-Wan Liu, Neng-Zhuo Feng, Shuang-Ze Zhong, Shang-Jin Chen, Jing-Wei He* and Jian Liang*
Background: Bladder Cancer (BLCA) is one of the most common human cancers its incidence is on the rise, especially in females. The Tumor Micro Environment (TME) acts a significant part in the development and progression of the tumor. We surveyed the expression profiles of BLCA in the Cancer Genome Atlas Program database and investigated genes that might affect the composition of the Tumor Micro Environment (TME). We then analyzed the relationship between genes and tumor prognosis, looking for immune prognostic markers which might lead to new styles for the diagnosis and treatment of BLCA.
Methods: We got the RNA-seq data of BLCA from The Cancer Genome Atlas (TCGA); utilized the Estimation of Stromal and Immune Cells in the Malignant Tissues Expression (ESTIMATE) data algorithm to compute the immune and stromal score. The differentially expre.. View More»
DOI:
10.4172/2167-7700.22.10.157