Rheumatology: Current Research
Open Access

Department of Internal Medicine, Albert Einstein College of Medicine, Jacobi Medical Center, New York, USA

Publications

• Mini Review   
  A Brief Review Highlighting the Broad Spectrum of Haemophagocytic Lymphohistiocytosis
  Author(s): Narvel H*, Mazzini J, Shao D, Mehta A, Kumar A and Yakkali S
  
  HLH is a rare, life-threatening condition characterized by an ineffective hyper stimulation of the immune system which leads to a pathologic rise in cytokine levels and to a hyper inflammatory state. Many conditions like Macrophage Activation Syndrome (MAS), sepsis, malignancies and even multi-inflammatory response syndrome after COVID 19 infection share overlapping clinical presentation and laboratory findings with HLH. Our review aims to provide updated clinical-practical generalities of HLH in terms of epidemiology, pathophysiology, clinical features, and management particularly in light of COVID19. The etiology of HLH can be classified as familial or secondary/ sporadic. The differentiation of primary and secondary HLH is very important because primary HLH may require different treatment modalities like hematopoietic stem cell transplantation. Since the emergence of the SARS-CoV2 .. View More»
  DOI: 10.35841/2161-1149.22.12.313

  Abstract HTML PDF