Department of Immunology, Shiraz University of Medical Sciences, Zand St, 71348-45794 Shiraz, Iran
While preparing her PhD, Dr. Shirin Farjadian worked on "HLA gene diversity among different ethnic groups of Iran". Due to its pivotal geographic location along the Silk Road, Iran has been a gateway of reciprocal human migrations between Asia and Europe. Iran shares an extended border with neighboring countries and the population of the country is genetically admixed. In addition to HLA genes, Dr. Shirin Farjadian has studied other polymorphic genes (including uniparental DNA polymorphisms) to trace the genetic history of Iranians and compare it with their cultural history.
Research Article
Increased Frequency of KIR2DS4 del/del among AA Genotype Carriers with B-Cell Acute Lymphoblastic Leukemia in Southwestern Iranian Population
Author(s): Sepide Namdari, Mohammad Reza Bordbar, Omid Reza Zekavat and Shirin Farjadian*
Acute Lymphoblastic Leukemia (ALL) is known to be the most common malignancy among children. The early onset of ALL suggests a key role of genetic factors in its development. Killer Cell Immunoglobulin-like Receptor (KIR) gene complex that encodes a group of key receptors expressed at the surface of natural killer cells has been of great interest as a possible genetic factor affecting the susceptibility to ALL. In this case-control study, we aimed to verify whether the inheritance of specific KIR genes or genotypes were associated with susceptibility to childhood B-ALL in southwestern Iranian population. To this end, KIR genotyping was carried out for 120 patients with childhood B-ALL and 170 unrelated healthy controls using PCR-SSP method. The frequencies of 11 KIR genes and KIR2DS4 variants were investigated among patients and healthy controls. We found no association between KIR ge.. View More»
DOI:
10.35248/igoa.21.6.134