Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Department of Biotechnology, Dr. B. Lal Institute of Biotechnology (BIBT), Jaipur, Rajasthan, India
Research Article
In Vitro Potency of Combinatorial Antifungal Drugs towards Candida Isolates from Patients
Author(s): Sakshi Agarwal, Smitanjali Parida, Bhuvnesvri Jadoun, Shreya N Patel, Sumit Moolchandani, Himanshu Puniyani, Raviranjan Kumar Pandey, Mandvi Mathur, Sandeep K Shrivastava and Aakanksha Kalra*
Candidiasis is a fungal infection (mycosis) caused by an opportunistic yeast with only 8-10 pathogenic species. In spite of the multiple classes of antifungal drugs available to combat these infections, the treatment is hampered by drug toxicity, tolerability, emergence of drug resistant isolates and many more. Combination therapy has been suggested as a possible approach to improve these treatment outcomes. This study is, therefore, aimed at the analysis of the sensitivity of Candida isolates obtained from patients towards different classes of drugs affecting multiple pathways in the pathogen life cycle. Four different individual drugs with different mechanisms of action and six different combinations of these drugs at three different proportions (1:1, 1:3, and 3:1) were used for the study. All the drug sensitivity assays were performed by the agar well diffusion method. The.. View More»
DOI:
10.35248/2165-8056.22.12.203