Journal of Cell Science & Therapy
Open Access

Peking-Tsinghua Center for Life Sciences, National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China

Biography

Sijie Liu is now   Assistant Professor, Department of Materials Science and Engineering, College of Engineering, Peking University.
Postdoctoral Fellow, Department of Physics and Astronomy, Northwestern University??????.

 

Publications

• Mini Review   
  A Recently Discovered Essential Factor for DNA Homologous Recombination: RNA Polymerase III
  Author(s): Sijie Liu*, Xiaoqin Liu and Daochun Kong*
  
  End resection is a central step in DNA homologous recombination (HR) and the HR-mediated repair of DNA double-strand breaks (DSBs), which degrades 5’-end strands at DSBs by several kilo-bases and thus creates 3’-end single-strand DNA overhangs. A critical long-standing question is how the 3’-end strands are protected during end resection. Now, this question is answered. Liu et al. found that the protection of 3’-end strands is achieved by the formation of an RNA-DNA hybrid. RNA polymerase III is responsible for catalyzing the RNA strand in the hybrid. Thus, RNA polymerase III is an essential factor for HR, and the RNA-DNA hybrid is an essential HR intermediate... View More»
  DOI: 10.35248/2157-7013.21.12.302

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