Journal of Leukemia
Open Access

Department of Biology and Ecology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine

Publications

• Research Article   
  Centromere and Genome Instability in Patients with Acute Leukemia
  Author(s): Sirenko Artur*
  
  The phenomena of Premature Centromere Division (PCD) of metaphase chromosomes and premature anaphase (Canaphase) in 57 patients with Acute Lymphoblastic Leukemia (ALL) and 32 patients with Acute Myeloblastic Leukemia (AML) were investigated. It was found that the levels of PCD and C-anaphase in patients with acute leukemia in the first acute period of the course of the disease in both peripheral blood and red bone marrow significantly exceed these indicators in the control group (healthy blood and red bone marrow donors). During the period of remission, the values of PRC and C-anaphase decreased and approached the values of the control group. The phenomena of PRC and C-anaphase can be used as additional non-specific diagnostic criteria for the course of ALL and AML. A high positive correlation was found between the level of blasts in peripheral blood and the level of PCD in peripheral.. View More»
  DOI: 10.35248/2329-6917.24.12.377

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