Journal of Chromatography & Separation Techniques
Open Access

Department of Pharmaceutical Analysis, J.S.S. College of Pharmacy, Tamilnadu, India

Publications

• Research   
  Determination of Pseudoephedrine HCL and Levocetirizine HCL in Combination Dosage Form by High Pressure Liquid Chromatography
  Author(s): Arunadevi S. Birajdar* and SN Meyyanathan
  
  An accurate and reproducible liquid chromatographic assay method was developed and validated for the determination of Pseudoephedrine HCL and Levocetirizine HCL in Tablet formulation. Acetonitrile and Water (50:50 v/v) was used for reverse-phase liquid chromatography at detection wavelength 230 nm to determine the contents of Pseudoephedrine HCL and Levocetirizine HCL in Tablet formulation. The method was validated by determining parameters such as specificity, linearity, LOD and LOQ, precision, accuracy, ruggedness and robustness. The method was found to be specific against placebo interference. Linearity was evaluated over the concentration range of Pseudoephedrine HCL 10-120.0 μg/mL and Levocetirizine HCL 0.5 to 12.0 μg/mL. The correlation of coefficient obtained was 0.998 for both. The intraday and interday precision values of the system and method was determined. The accura.. View More»
  DOI: 10.35248/2329-9096-22.10.629

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