Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
ISSN: ISSN: 2157-7412
Department of Zoology, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India
Review Article
Duchenne Muscular Dystrophy: A Review on Systemic Paradigm Approaching Diagnosis to Therapy
Author(s): Srabaita Roy*, Ranjit Shaw*, Sukanya Samaddar, Sukanya Samanta, Ritwija Maity, Puja Chatterjee, Ankita Das, Suchismita Bhaumik and Gyaneshwer Chaubey
Duchenne Muscular Dystrophy (DMD) is a severe congenital disorder caused by DMD gene mutations, which
results in muscular degeneration and movement difficulties, eventually leading to death. Whereas its less severe
form, Becker Muscular Dystrophy (BMD), also caused by the DMD gene mutations, shows slower patterns of
progression with much later onset. This review discusses the various mutations resulting in DMD, its genetic basis,
the diagnostic tools for performing a genetic diagnosis of having DMD and also advocates the necessity of having
genetic therapies and employing nutraceuticals for therapy in the context of this disease. Furthermore, we have also
highlighted several treatment options, such as antibacterial drugs, AON-mediated exon skipping therapy, Clustered
Regularly Interspaced Short Palindromic Repeats (CRISPR-Cas9) gene-editing technology, nutraceutic.. View More»
DOI:
10.35248/2157-7412.24.15.413