Journal of Drug Metabolism & Toxicology
Open Access

Department of Pharmaceutical Analysis and Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534202, AP, India

Biography

Dr. Srinivasa Rao A is an Associate professor in the Department of Pharmaceutical Analysis and Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, located in Bhimavaram and published 12 articles and 279 citations in many journals and the articles are informative and got good citations. He done one project is Novel process for the isolation of Solanesol of high purity and its conversion to Coenzyme Q10. Sanctioned by AICTE-New Delhi, under Research Promotion Scheme.

Publications

• Research Article   
  Analytical Method Development and Validation for the Estimation of Silodosin and Dutasteride in Capsule Dosage Form by RP-HPLC Method
  Author(s): Nataraj KS*, Srinivasa Rao A and Harshitha S
  
  A simple, rapid, accurate, efficient and reproducible reverse phase high performance liquid chromatography (RPHPLC) method was developed and subsequently validated for simultaneous estimation of silodosin and dutasteride capsules. The analysis was carried out using Unison C8 column (250 mm x 4.6, 5 μm particle size) at 40°C temperature using mobile phase buffer:Methanol:Acetonitrile (20%:40%:40% v/v/v) at flow rate 1.0 ml/min. Quantification was achieved with PDA detector at a wavelength of 275nm. The silodosin peak retention time was 2.4 mins and the dutasteride retention was 10.9 mins, so the total run time was set to 14mins. The linearity range of Silodosin and Dutasteride is 20-120 μg/ml and 1.25-7.5 μg/ml respectively. Linear regression found to be 0.999. The proposed method was validated according to International Conference on Harmonisation (ICH) guidelines. The re.. View More»
  DOI: 10.35248/2157-7609.20.11.245

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