Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Medical Laboratory Sciences, Universitatsklinikum Regensburg, Regensburg, Germany
Dr. Stefan Wallner is currently working in department of Laboratory Medicine and Clinical Chemistry, University of Regensburg, Germany. He is working for projects: epigenomic analysis of adipocytes, blood monocytes (CD14+,CD33+) and macrophages (CD68+ M1/M2), on investigation of the long term influence of environmental effects, on analysis of miRNA patterns in immunomagnetic nanobead isolated monocytes in diabesity and fully expressed metabolic syndrome as well as analysis of 40 ranked miRNAs.
In cooperation with Subproject 4.1, adipocyte epigenetics will be coupled with analysis of hepatocytes of NAFLD patients.
Research work include: Phosphatidylcholine and phosphatidylethanolamine plasmalogens in lipid loaded human macrophages,etc.
Research Article
Evaluation of a Multimarker Panel in Chronic Heart Failure: A 10 Years Follow-Up
Author(s): Susanne Bauer*, Christina Strack, Ute Hubauer, Ekrem Ücer, Stefan Wallner, Andreas Luchner, Lars Maier and Carsten Jungbauer
Background: Chronic heart failure is a complex disease associated with various pathophysiological and biochemical
disorders. We assessed the 10 years prognostic role of a multimarker panel of markers for myocyte stress (GDF-15),
extra-cellular matrix remodeling (Galectin-3, mimecan, TIMP-1), inflammation (Galectin-3), myocyte injury (hs-TnT)
and angiogenesis (endostatin, IBP-4, IGF-BP-7, sFlt-1 and PLGF) head-to-head with the biochemical gold-standard
NT-proBNP.
Methods: Blood samplesfrom 149 patients with heart failure were analysed. After 10 years of follow-up (median
follow-up 104 months, IQR 43-117), data regarding rehospitalisation for chronic heart failure and all-cause-mortality
were acquired.
Results: Regarding Kaplan Meier analysis, all markers, dichotomized according to you denindex,.. View More»