Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Department of Internal Medicine, Rheumatology Division, University of Michigan, Ann Arbor, USA
He belongs from Department of Internal Medicine, Rheumatology Division in University of Michigan, Ann Arbor at USA. His Subjects of Specialization are Nephrology, Rheumatology, Health , Development biology, Flow Cytometry,Immunity, health , medical sciences.
Research
Anti-KIR Antibodies Treat Lupus in Mice
Author(s): Strickland FM, Johnson KJ and Richardson BC*
Epigenetically altered T cells cause lupus in genetically predisposed mice, and similar T cells are found in patients with active lupus. More recent reports demonstrate that the epigenetically altered cells comprise a novel CD4+CD28+ T cell subset characterized by co-overexpression of genes normally suppressed by DNA methylation, including those encoding CD11a, CD70, CD40L and the killer cell immunoglobulin-like receptor (KIR) gene family. Inducing a T cell DNA methylation defect in lupus-prone mice causes a similar subset and lupus. Since KIR genes are not expressed by normal T cells, we tested if antibodies to KIR proteins treat lupus in in mice. A cytotoxic antibody to murine KIR proteins was generated and injected into lupus-prone mice with a T cell DNA methylation defect. The antibody prevented the development of glomerulonephritis in the mice. This suggests tha.. View More»