Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Center for Exosome and Bioparticulate Research, Hanyang University, Gyeonggi-do,15588, Korea
Research Article
Neuroprotective Effect of Glial Cell-Derived Exosomes on Neurons
Author(s): Sujin Hyung, Ju Young Kim, Chan Jong Yu, Hyun Suk Jung and Jong Wook Hong*
Recent research has revealed that exosomes affect several aspects of organism physiology and development, as well as disease processes, through intracellular communication. However, the biological roles of exosomes in exosomesecreting cells have remained largely unexplored. In this study, we demonstrate that Schwann cell (SC)-derived exosomes (EXOSC) promote cell survival among motor neurons (MNs), with MN viability exceeding 80% at days in vitro (DIV) 14. Prevention of MN cell death by EXOSC was achieved by blocking the caspase-3 cell death pathway, which was confirmed by comparing the number of activated-caspase3+ cells according to the presence versus absence of EXOSC. The attenuation of exosome secretion from SCs by treatment with GW4869 resulted in increased MN cell death, regardless of SC viability. Together, these findings enhance our understand.. View More»
DOI:
10.35248/2471-9552.19.5.156