ISSN: 2736-6588
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Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan
Research Article
Scaffold-Directed and Traceless Synthesis of Tricyclic Quinoxalinone Imidazoles under Microwave Irradiation
Author(s): Suman Thummanagoti*
Traceless synthesis of 2-aminoimidazoquinoxalinones has been performed on soluble polymer support under openvessel
microwave dielectric heating. The reaction progression is monitored directly by the conventional proton
Nuclear Magnetic Resonance (NMR) without release of the substrate from the support. Fmoc-deprotected amino
acid polymer conjugates react with 1,5-difluoro-2,4-dinitro benzene to yield polymer bound dinitro fluoro amines,
which are further substituted by various primary amines to yield PEG-immobilized dinitro diamines. Simultaneous
reduction of aromatic meta-dinitro group leads to the traceless release of 2-qunoxalinones, followed by N-hetero
cyclization with various isothiocyanates in the presence of mercury (II) chloride to furnish 2-aminoimidazoquinolinone
rings with three points of diversity at rapid pace... View More»
DOI:
10.35248/JCCLM.23.6.267