Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Applied Chemistry, National Chiao Tung University, Hsinchu, 30010, Taiwan
Research Article
Microwave Assisted Tandem Transformation Led to Pyrrolo, Pyrido- Benzimidazolones and Isoindolo-Benzimidazolones on Ionic Liquid Support
Author(s): Suman Thummanagoti*
In this paper we have explored an ionic liquid as a matrix liquid to generate small molecule library on homogeneous phase soluble medium. In this context a rapid and effective method to prepare various isoindolo (2,l-a) benzimidazolone, pyrrolo (1,2-a) benzimidazolone and pyrido (1,2-a) benzimidazolone libraries on ionic liquid support by using focused microwave irradiation was described. The 4-fluoro-3-nitrobenzoic acid has been used as a building block to generate the benzimidazole heterocyclic core for library diversity through the ionic liquid supported multistep synthesis. Thereby various primary amines have been used to displace the fluorine atom through the nucleophilic substitution and subsequent reduction led to the IL supported conjugate diamine. The obtained conjugate diamne used as a scaffold to generate various ring size heterocyclic libraries via one pot intermo.. View More»
DOI:
10.35248/2736-6588.24.7.294