Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Agriculture and Agri-Food Sciences, Guelph Food Research Center, Ontario, Canada
Research Article
Raffinose Family Oligosaccharides and the Synbiotic with Probiotic Lactic Acid Bacteria Modulate Immune Systems: Through Inhibiting the Cytokine Production
Author(s): Gui-Ying Mei, Joshua Tang, Christine M. Carey, Susan Tosh and Magdalena Kostrzynska*
Probiotics and prebiotics are known to benefit the host through modulating immune functions in multiple ways. In this study, selected probiotic lactic acid bacteria strains, various prebiotics, and synbiotic combinations of probiotics and prebiotics were investigated for anti-inflammatory effects in vitro models. Secreted Interleukin-8 (IL-8) from HT-29 cells was monitored as an inflammation parameter. Individually, the prebiotics raffinose, stachyose, verbascose, oligomate 55NP and beta-glucan decreased the secretion of IL-8 from stimulated HT-29 cells, as compared to stimulated HT-29 medium controls. With the exception of Bifidobacterium longum ATCC 15703, all the tested probiotic bacteria individually reduced secreted IL-8 levels. Synbiotic combinations of the tested probiotics with raffinose, soy extract or oligomate 55NP significantly reduced the IL-8 .. View More»
DOI:
10.35248/2329-8901.22.10.288