Translational Medicine
Open Access

Department of Anaesthesiology and Intensive Care, Hospital Komarno, Slovakia

Publications

• Systematic Review   
  Portrayal of the Multitasking Complement Regulator One in Critical Illness
  Author(s): Sylvia Frisancho-Kiss*
  
  The complement system is one of the evolutionary ancient, primordial components of the immune system. As such, it was destined to fulfill most aspects of the immune response with built-in self-limiting regulatory components. While new and new layers of immune repertoire evolved, complement retained its influential role in recognition, phagocytosis, clearance, antibody diversity, adaptive immune response and regulation. In essence the complement system is an innate patent recognition niché, serving to process pathogens, clearing debris and to condition adaptive immunity. The three complement amplification pathways are individually or in combination regulated by soluble and membrane bound complement regulators, Regulator of Complement Activation (RCAs). Among them Complement Regulator-1(CR1) stands out for diversity of functions, and may be of particular inte.. View More»
  DOI: 10.35248/2161-1025.23.13.288

  Abstract HTML PDF