Rheumatology: Current Research
Open Access

Department of Rheumatology, Imam Al-Sadiq Teaching Hospital, Babylon, Iraq

Publications

• Case Report   
  Melanonychia is an Adverse Effect of TNF Inhibitors (Adalimumab) in Psoriatic Arthritis Patient: A Case Report
  Author(s): Tahir Hussein Alsaadawi*
  
  Introduction: Melanonychia, derived from the Greek terms "melas" (black) and "onyx" (nail), is characterized by brown-black discoloration of the nail plate, primarily due to melanin production. This condition can arise from two mechanisms: Melanocytic activation and melanocyte proliferation. Case presentation: A fully human monoclonal antibody targeting Tumor Necrosis Factor (TNF), adalimumab is used to treat several immune-mediated inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, and Crohn's disease. Skin-related adverse effects account for approximately 25% of all reported side effects of anti- TNF therapies, which may only become apparent in clinical practice despite thorough preclinical studies.  Results: This case report suggests that adjusting the freque.. View More»
  DOI: 10.35841/2161-1149.24.14.428

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